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Niacin occurs naturally in many foods, including greens, meat, poultry, fish, and eggs, although in a fraction of the dose shown to achieve changes in cholesterol. Many products are also fortified with niacin during manufacturing. What are the risks of taking niacin?
Taking high doses of niacin has been shown to produce the following improvements in blood cholesterol and lipids: Specifically, niacin is a major component of NAD and NADP, two coenzymes involved in cellular metabolism. The U.S. Department of Agriculture's (USDA's) FoodData Central lists the nutrient content of many foods and provides a comprehensive list of foods containing niacin arranged by nutrient content . Dietary supplements Because absorbability can significantly vary depending on the form of niacin used, it’s a good idea to ask your healthcare provider what form would be best for your specific health needs. summary
Aspirin will also help to reduce the flushing. If you are already taking low-dose aspirin (81 to 325 mg daily) try taking it about 30 minutes before your first niacin dose of the day. If you stop taking Flush Free Niacin for any length of time, talk with your doctor before starting the medication again. You may need to restart the medication at a lower dose. A study published in 2015 in the Medical Science Monitor revealed that in animal subjects, niacin was able to inhibit vascular inflammation and also inhibit apoptosis (programmed cell death) of of vascular smooth muscle cells. Overall, niacin appeared to inhibit the progress of atherosclerosis in animal subjects. ( 11) 4. Detoxes the Body
Other sources suggest that although inositol nicotinate reduces or prevents flushing, it may not provide the body with high enough levels of niacin to lower cholesterol. To put that in perspective, the recommended daily intake for most men and women is 14–16 mg per day ( 9, 10). Although uncommon, switching from an immediate-release niacin to a long-acting niacin or significantly increasing your dose can result in serious liver damage ( 27).
Should I take no-flush niacin?
In one observational study of over 12,000 adults, researchers found that each 1 mg increase in daily niacin intake was associated with a 2% decrease in high blood pressure risk — with the lowest overall high blood pressure risk seen at a daily niacin intake of 14.3 to 16.7 mg per day ( 8). Tryptophan is another food source of niacin because this amino acid—when present in amounts beyond that required for protein synthesis—can be converted to NAD, mainly in the liver [ 3, 5]. The most commonly used estimate of efficiency for tryptophan conversion to NAD is 1:60 (i.e., 1 mg niacin [NAD] from 60 mg tryptophan). Turkey is an example of a food high in tryptophan; a 3-oz portion of turkey breast meat provides about 180 mg tryptophan, which could be equivalent to 3 mg niacin [ 9]. However, the efficiency of the conversion of tryptophan to NAD varies considerably in different people [ 3]. Pellagra is uncommon in industrialized populations and is mostly limited to people living in poverty, such as refugees and displaced people who eat very limited diets low in niacin and protein [ 21, 22]. Pellagra was not uncommon in the early 20th century among individuals living in poverty in the southern United States and parts of Europe whose limited diets consisted mainly of corn [ 2, 3]. The World Health Organization recommends treating pellagra with 300 mg/day nicotinamide in divided doses for 3–4 weeks along with a B-complex or yeast product to treat likely deficiencies in other B vitamins [ 21]. Risks. Niacin does have risks. It can cause liver problems, stomach ulcers, changes to glucose levels, muscle damage, low blood pressure, heart rhythm changes, and other issues. People with any health condition including liver or kidney disease, diabetes, high blood pressure, or cardiovascular problems need to talk to a doctor before using niacin supplements. Do not treat high cholesterol on your own with over-the-counter niacin supplements. Is a niacin flush dangerous? High doses of niacin have been associated with liver damage, gastrointestinal problems, glucose intolerance, low blood pressure, heart rhythm changes and other health issues. This is why it’s important to speak with your health care provider about the appropriate niacin supplement and dose for your particular needs.
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